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9912 matches
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organism
protein
1)
Homo sapiens
IRGM - Immunity-related GTPase family M protein;
Putative
GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune
response
probably through
regulation
of autophagy. May
regulate
proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity). Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
[a.k.a. H0YBM2, IRGM1, ENSG00000237693]
2)
Homo sapiens
DOK4 - Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity).
Putative
link with downstream effectors of RET in neuronal differentiation. May be involved in the
regulation
of the immune
response
induced by T-cells.
[a.k.a. NM_001369621.1, XM_024450347.1, ENST00000566705.5]
3)
Homo sapiens
TRPV3 - Transient receptor potential cation channel subfamily V member 3;
Putative
receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased
response
at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative
regulator
of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
[a.k.a. R-HSA-3295583, UPI00005054EE, I3L0L5]
4)
Mus musculus
Irgm1 - Immunity-related GTPase family M protein 1;
Putative
GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune
response
probably through
regulation
of autophagy. May
regulate
proinflammatory cytokine production and prevent endotoxemia upon infection. Required for macrophage motility and possibly also for adhesion. Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
[a.k.a. ENSMUST00000147151, LPS-stimulated RAW 264.7 macrophage protein 47, XP_011247066.1]
5)
Mus musculus
Dok4 - Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity).
Putative
link with downstream effectors of RET in neuronal differentiation. May be involved in the
regulation
of the immune
response
induced by T-cells (By similarity).
[a.k.a. 114255, Docking protein 4, Dok4-201]
6)
Mus musculus
Trpv3 - Transient receptor potential cation channel subfamily V member 3;
Putative
receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased
response
at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative
regulator
of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By simi [...]
[a.k.a. AI644701, R-MMU-983712, NP_659567]
7)
Drosophila melanogaster
p38c -
Putative
mitogen-activated protein kinase 14C; P38c MAP kinase (p38c) encodes a protein involved in the stress and wound
responses
,
regulating
the expression of Duox and Ddc.
[a.k.a. FBgn0267339, p38c-PA, FBpp0083967]
8)
Caenorhabditis elegans
odr-1 - Receptor-type guanylate cyclase gcy-10; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).
Regulates
chemotaxis
responses
toward volatile odorants in AWC sensory neurons and their avoidance in AWB sensory neurons. May be involved in sensitivity to quinine by
regulating
egl-4 activity through the production of cGMP. Involved in phototransduction in ASJ neurons downstream of G protein coupled-photoreceptor lite-1. Required to maintain the expression of
putative
olfactory receptor str-2 in AWC neurons in adults. In AWB and AWC sensory neurons, media [...]
[a.k.a. NP_510266, Q9NGZ8, Receptor-type guanylate cyclase gcy-10]
9)
Caenorhabditis elegans
hda-2 -
Putative
histone deacetylase 2; Probably
responsible
for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional
regulation
, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase e [...]
[a.k.a. C08B11.2, Q09440, C08B11.2.1]
10)
Escherichia coli K12
yhjB -
Putative
DNA-binding transcriptional
response
regulator
;
Putative
regulator
; Protein involved in transcription activator activity and transcription.
[a.k.a. b3520, AAC76545.1, NP_417977]
11)
Escherichia coli K12
yhaJ - LysR family
putative
transcriptional
regulator
; Positive
regulator
, may be partially
responsible
for expression of neighboring gene dlsT (yhaO) (By similarity).
[a.k.a. b3105, AAC76140.1, JW3076]
12)
Escherichia coli K12
yehT -
Putative
response
regulator
in two-component system withYehU; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsR
regulates
expression of btsT by binding to its promoter region. Activation of the BtsS/BtsR signaling cascade also suppresses YpdA/YpdB-mediated yhjX induction.
[a.k.a. AAC75186.2, b2125, DNA-binding transcriptional activator BtsR]
13)
Saccharomyces cerevisiae
YOR387C - VEL1-related protein YOR387C;
Putative
protein of unknown function;
regulated
by the metal-
responsive
Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YOR387C has a paralog, VEL1, that arose from a single-locus duplication.
[a.k.a. NM_001183807.3, Q08910, UPI000006AEAF]
14)
Saccharomyces cerevisiae
ASR1 - Alcohol-sensitive RING finger protein 1; Ubiquitin ligase that modifies and
regulates
RNA Pol II; involved in a
putative
alcohol-
responsive
signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein.
[a.k.a. YPR093C, sce:YPR093C, Q06834]
15)
Saccharomyces cerevisiae
YMR315W - Uncharacterized protein YMR315W; Protein with NADP(H) oxidoreductase activity; transcription is
regulated
by Stb5p in
response
to NADPH depletion induced by diamide; promoter contains a
putative
Stb5p binding site; protein abundance increases in
response
to DNA replication stress.
[a.k.a. S000004932, 4932.YMR315W, AAS56317.1]
16)
Saccharomyces cerevisiae
YHL026C - Uncharacterized protein YHL026C;
Putative
protein of unknown function; transcriptionally
regulated
by Upc2p via an upstream sterol
response
element; SWAT-GFP fusion protein localizes to the cell periphery, while mCherry fusion localizes to both the cell periphery and vacuole; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History).
[a.k.a. 856359, UPI00005E6FA6, NM_001179106]
17)
Saccharomyces cerevisiae
OAF3 - Oleate activated transcription factor 3;
Putative
transcriptional repressor with Zn(2)-Cys(6) finger; negatively
regulates
transcription in
response
to oleate levels, based on mutant phenotype and localization to oleate-
responsive
promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress.
[a.k.a. YKR064W, P36023, S000001772]
18)
Saccharomyces cerevisiae
YGR127W - Uncharacterized protein YGR127W;
Putative
protein of unknown function; expression is
regulated
by Msn2p/Msn4p, indicating a possible role in stress
response
.
[a.k.a. YG37_YEAST, NP_011643, P53275]
19)
Saccharomyces cerevisiae
YML083C -
Putative
uncharacterized protein YML083C; Protein of unknown function; transcriptionally
regulated
by Upc2p via an upstream sterol
response
element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions.
[a.k.a. 854891, YML083C_mRNA, NM_001182442.1]
20)
Saccharomyces cerevisiae
YRO2 - Protein with a
putative
role in
response
to acid stress; null mutant is sensitive to acetic acid; transcription is
regulated
by Haa1p and induced in the presence of acetic acid; protein observed in plasma membrane foci in the presence of acetic acid; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; Belongs to the archaeal/bacterial/fungal opsin family.
[a.k.a. YBR054W, NP_009610.1, P38079]
9912 matches
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